What Is IVF Treatment? A Complete Guide to the Process, Success Rates, Cost and Risks
Quick answer: what is IVF treatment?IVF (in vitro fertilization) is a fertility treatment in which eggs are collected from the ovaries, fertilized with sperm in a laboratory, and the resulting embryo...
| Quick answer: what is IVF treatment?IVF (in vitro fertilization) is a fertility treatment in which eggs are collected from the ovaries, fertilized with sperm in a laboratory, and the resulting embryo is placed in the uterus to try to achieve pregnancy. It is a form of assisted reproductive technology (ART) and is commonly advised for blocked fallopian tubes, male-factor infertility, endometriosis, ovulation disorders, age-related decline in egg quality and unexplained infertility. One cycle usually takes about 2 to 3 weeks of active treatment, and the chance of a baby per cycle depends mainly on the age of the woman whose eggs are used. |
If you have been trying to conceive for a long time, the words “IVF treatment” can feel both hopeful and overwhelming. What exactly happens to your body? Is the procedure painful? What are the real chances of success at your age? How much will it cost, and what are the risks? These are the questions couples ask us most often, and they deserve straight, evidence-based answers instead of vague promises.
Table Of Content
- What Is IVF Treatment?
- How common is infertility, and how common is IVF?
- IVF at a glance
- How IVF fits into natural conception
- Who Needs IVF Treatment?
- When should you see a fertility specialist?
- Before You Start: Tests and Decisions
- Decisions to think through before your cycle
- IVF Treatment Step by Step: What Happens in a Cycle
- Step 1: Cycle control (before stimulation)
- Step 2: Ovarian stimulation (about 8 to 14 days)
- Common IVF medicines and what they do
- Step 3: The trigger injection
- Step 4: Egg retrieval (egg pick-up)
- Step 5: Sperm collection and preparation
- Step 6: Fertilization in the laboratory
- Step 7: Embryo development and grading
- Step 8: Optional lab procedures
- Step 9: Embryo transfer
- Step 10: The two-week wait and pregnancy test
- What if the cycle is cancelled or no embryo can be transferred?
- IVF timeline at a glance
- Types of IVF and Related Procedures
- IVF vs IUI: What Is the Difference?
- IVF Add-Ons: What Has Evidence and What Does Not
- IVF Success Rates: What Are Your Chances?
- Live birth rate by age (per egg retrieval)
- Factors that affect success
- Why IVF cycles fail
- How Much Does IVF Treatment Cost in India?
- What affects the final bill?
- IVF Risks, Side Effects and Safety
- Common side effects of fertility medicines
- Less common but important risks
- Life After Embryo Transfer: The Two-Week Wait
- What is normal
- Practical tips for the wait
- If the test is positive
- If the test is negative
- How to Prepare Your Body for IVF
- IVF and Emotional Wellbeing
- IVF in India: The ART (Regulation) Act, 2021
- How to Choose an IVF Clinic
- Questions to ask at your first consultation
- Alternatives to IVF
- IVF Myths vs Facts
- IVF Glossary: Terms You Will Hear
- How Dr Curo Supports Your Fertility Journey
- Frequently Asked Questions About IVF Treatment
- Conclusion: Is IVF Right for You?
This guide explains IVF treatment from start to finish: what it is, who needs it, the tests you will need first, every step of an IVF cycle, the different types of IVF, the add-ons you may be offered (and which ones are backed by evidence), success rates by age, cost in India, risks, life after embryo transfer, Indian law, how to choose a clinic and the questions to ask. Wherever we quote numbers, we point to the source so you can check them yourself. For a service overview, you can also visit our page on IVF treatment in India.
| Key takeaways• IVF fertilizes eggs outside the body and transfers the resulting embryo into the uterus; it is the most effective fertility treatment that involves handling eggs, sperm and embryos.• Age is the strongest predictor of success. In US national data, live births per egg retrieval fall from about 47% under 35 to about 3% at 43 and above.• A typical cycle has five stages: ovarian stimulation, egg retrieval, fertilization and embryo culture, embryo transfer, and a two-week wait before the pregnancy test.• Serious complications such as OHSS, multiple pregnancy and ectopic pregnancy are uncommon, but you should know the warning signs.• Many add-ons sold alongside IVF have little or no high-quality evidence. Ask what each one is expected to achieve and what it costs.• In India, IVF is regulated by the ART (Regulation) Act, 2021. Treat only at a registered ART clinic. |
What Is IVF Treatment?
IVF stands for in vitro fertilization. “In vitro” is Latin for “in glass”, a reference to the laboratory dish in which an egg and sperm are brought together. In natural conception, fertilization happens inside a fallopian tube. In IVF it happens in an embryology laboratory. The fertilized egg, now called an embryo, is monitored for several days and then one or more healthy embryos are placed into the uterus. A pregnancy begins only if an embryo implants in the uterine lining.
You may have heard the phrase “test-tube baby”. It is a popular way of describing a baby born through IVF, although fertilization takes place in a shallow culture dish, not a test tube. After the first few days in the lab, the embryo grows inside the mother like any other pregnancy.
According to Mayo Clinic, IVF is the most effective type of fertility treatment that involves the handling of eggs or embryos and sperm. Together, these treatments are grouped under the name assisted reproductive technology (ART). IVF can use a couple’s own eggs and sperm, or eggs, sperm or embryos from a donor. In some cases a gestational carrier, a woman who carries an embryo created from the intended parents’ or donors’ gametes, is used.
How common is infertility, and how common is IVF?
Infertility is far more common than most people think. A World Health Organization report estimates that about 17.5% of adults, roughly 1 in 6 people, experience infertility at some point in life, with similar rates in high-income countries (17.8%) and low- and middle-income countries (16.5%). The same report defines infertility as the failure to achieve a pregnancy after 12 months or more of regular unprotected intercourse, and highlights that treatment, including IVF, remains underfunded and out of reach for many because of cost. In November 2025 WHO also published global guidelines on the prevention, diagnosis and treatment of infertility.
Cleveland Clinic reports that more than 8 million babies have been born through IVF since 1978, and that IVF is one of the most effective assisted reproductive technologies available.
IVF at a glance
| Feature | What to expect |
| What it is | Eggs are fertilized by sperm in a laboratory and the embryo is transferred into the uterus |
| Length of one cycle | About 2 to 3 weeks from the start of stimulation to transfer (Mayo Clinic); about 4 to 6 weeks including preparation up to the pregnancy test (Cleveland Clinic) |
| Ovarian stimulation | Daily hormone injections, usually 8 to 14 days, with scans and blood tests |
| Egg retrieval | Around 20 minutes under sedation; eggs are collected using an ultrasound-guided needle |
| Embryo transfer | Usually under 10 minutes, typically without anaesthesia |
| Pregnancy test | A blood test about 9 to 14 days after embryo transfer, depending on the clinic |
| Who it helps | Tubal disease, male-factor infertility, endometriosis, ovulation problems, unexplained infertility, age-related decline, genetic risk and fertility preservation |
How IVF fits into natural conception
To understand IVF, it helps to know what normally happens. After ovulation, an egg is picked up by a fallopian tube. Sperm must swim from the vagina through the cervix and uterus into the tube to meet the egg, where fertilization usually occurs, as explained in the ASRM patient guide to IVF. The embryo then travels to the uterus and implants. IVF reproduces this chain of events in a controlled setting, which is why it can bypass several different problems:
| Where conception breaks down | How IVF helps |
| Blocked or damaged fallopian tubes | The egg is collected directly from the ovary, so the tubes are bypassed |
| Few, slow or abnormally shaped sperm | Selected sperm are placed with the egg, or injected into it using ICSI |
| Irregular or absent ovulation | Medicines mature several eggs which are then collected |
| Endometriosis or low egg numbers | Multiple eggs can be collected and the best embryo selected |
| Risk of passing on a genetic condition | Embryos can be tested before transfer (PGT) |
| Need to preserve fertility | Eggs or embryos can be frozen for later use |
Who Needs IVF Treatment?
IVF is rarely the first step. Mayo Clinic notes that, before IVF, many couples can try treatments that involve fewer procedures, such as fertility medicines to help the ovaries release more eggs, or intrauterine insemination (IUI). IVF becomes the preferred option when those treatments have not worked, or when the underlying problem means they are unlikely to work. Common reasons include:
• Blocked or damaged fallopian tubes. If both tubes are blocked, the egg and sperm cannot meet and an embryo cannot travel to the uterus.
• Ovulation disorders. Conditions such as PCOS can mean eggs are released rarely or not at all. Read our detailed guide on PCOS and infertility and the Cleveland Clinic overview of PCOS.
• Endometriosis. Tissue similar to the uterine lining grows outside the uterus and can affect the ovaries, tubes and egg quality. See Cleveland Clinic on endometriosis.
• Uterine fibroids. These growths can make it harder for an embryo to attach to the lining; Mayo Clinic lists them among the reasons IVF may be considered (fibroids explained).
• Male-factor infertility. A low sperm count, poor movement or abnormal shape can reduce the chance of natural fertilization. Learn more about low sperm count and male infertility.
• Unexplained infertility. Tests find no clear cause, yet pregnancy does not occur.
• Age-related decline in egg quantity and quality. Mayo Clinic notes that IVF is sometimes offered as the main treatment for people over 40. See also advanced maternal age.
• Previous tubal ligation. IVF can be an option when a person cannot or does not want to undergo reversal surgery.
• Risk of a genetic disorder. Embryos can be tested through preimplantation genetic testing before transfer.
• Fertility preservation. Before cancer treatment such as chemotherapy or radiation, eggs or embryos can be frozen for the future.
• No working uterus or high-risk pregnancy. In some cases embryos are transferred to a gestational carrier, which is subject to Indian surrogacy law. See our comparison of IVF vs surrogacy.

When should you see a fertility specialist?
As a general guide, couples are advised to seek an evaluation after 12 months of trying without success if the woman is under 35, and after 6 months if she is 35 or older. Do not wait if you have very irregular or absent periods, known endometriosis or tubal disease, a previous pelvic infection or surgery, a known problem with semen quality, or a history of cancer treatment. An early evaluation often saves months, and sometimes years, of uncertainty. Our overview of infertility treatment options explains what the first consultation usually includes.
| Who can have IVF in India?Eligibility is defined by the Assisted Reproductive Technology (Regulation) Act, 2021, which came into force in January 2022. ART services may be commissioned by married couples or women within the age limits set by the Act (21 to 50 years for the woman and 21 to 55 years for the man, under Section 21(g)). Courts have been asked to interpret how these limits apply in specific situations, so please confirm your own eligibility with a registered ART clinic. We explain the law in more detail later in this guide. |
Before You Start: Tests and Decisions
A good IVF cycle starts weeks before the first injection. Both partners are evaluated so the doctor can choose the right protocol and medicine doses. Typical pre-IVF assessments, drawn from Mayo Clinic and Cleveland Clinic, include:
| Test or step | Why it matters |
| Ovarian reserve testing (AMH blood test and antral follicle count by ultrasound) | Estimates how many eggs are available and helps predict how your ovaries will respond to stimulation |
| Semen analysis | Checks sperm count, movement and shape; decides between conventional insemination and ICSI |
| Screening for infections | Both partners are tested for infections such as HIV and other infectious diseases, to protect the lab, the embryos and the baby |
| Uterine cavity evaluation (saline sonography or hysteroscopy) | Detects polyps, fibroids, scar tissue or other problems that could stop an embryo from implanting |
| Mock (practice) embryo transfer | Measures the length and direction of the uterus so the real transfer is smooth |
| Genetic carrier screening | Identifies inherited conditions that could be passed to a child |
| General health review | Pap test, and a mammogram for those over 40, along with other tests your doctor advises |
| Folic acid supplementation | Cleveland Clinic notes that supplementation usually starts at least three months before embryo transfer |
Decisions to think through before your cycle
• How many embryos will be transferred? This usually depends on age, embryo quality and the number of embryos available. Transferring more than one raises the chance of twins or triplets, which carry higher risks. Indian law also limits the number that can be transferred.
• What will happen to extra embryos? Extra embryos can be frozen and stored. Options for unused embryos, such as continued storage, donation or discarding, depend on the law and clinic policy, so decide this before embryos are created.
• How will you manage a multiple pregnancy? Discuss this possibility upfront. Mayo Clinic notes that reducing the number of foetuses is a major decision with ethical, emotional and medical considerations.
• Are you using donor eggs, donor sperm or a gestational carrier? Speak to a counsellor trained in donor and legal issues so you understand the rights, responsibilities and paperwork involved. Our guide to donor egg IVF covers this in detail.
• What is your budget for more than one cycle? Many couples need two or three attempts, so plan the finances and emotional energy accordingly.
IVF Treatment Step by Step: What Happens in a Cycle
Every clinic customises the protocol, but the core sequence is the same. Here is what happens at each stage, in the order you will experience it.
Step 1: Cycle control (before stimulation)
Some doctors prescribe birth control pills or estrogen for a short period before stimulation begins. According to Cleveland Clinic, this helps stop ovarian cysts from forming and controls the timing of your cycle, so that the maximum number of mature eggs can be collected on the day of retrieval. Not every protocol uses this step.
Step 2: Ovarian stimulation (about 8 to 14 days)
In a natural cycle, a group of eggs begins to develop each month, but usually only one matures and is released. In IVF, daily hormone injections encourage the whole group to mature together. More eggs mean more chances of creating a healthy embryo, because some eggs will not fertilize and some embryos will not develop normally.
The type and dose of medicine are tailored to your age, medical history, AMH level and previous response. Most stimulations last between 8 and 14 days. During this time you will have regular monitoring:
• Transvaginal ultrasound scans to measure the number and size of follicles, the fluid-filled sacs that contain the eggs. As a rule of thumb, follicles larger than about 14 mm are more likely to contain mature eggs.
• Blood tests for estradiol and other hormones, which show how your body is responding. Doses are adjusted based on these results.
Common IVF medicines and what they do
| Medicine | Purpose |
| Birth control pill or estrogen (before the cycle) | Controls cycle timing and prevents ovarian cysts |
| FSH and/or LH (gonadotropin injections) | Stimulate the ovaries to grow several follicles at once |
| GnRH agonist or antagonist | Prevents the eggs from being released too early |
| Trigger injection (hCG or a GnRH agonist) | Completes egg maturation; timed about 34 to 36 hours before retrieval |
| Progesterone, often with estrogen | Prepares and supports the uterine lining so an embryo can implant; often continued into early pregnancy as advised |
Your doctor decides which medicines to use, in what order and at what dose. Never change doses or timing on your own, and never skip the trigger injection time.
Step 3: The trigger injection
When scans and hormone levels show the eggs are ready, you are given a single trigger injection to complete egg maturation. The timing is critical: egg retrieval is scheduled 34 to 36 hours later, before ovulation would naturally occur. Your clinic will give you an exact time for the injection.
Step 4: Egg retrieval (egg pick-up)
Egg retrieval is a short procedure done under sedation or light anaesthesia. An ultrasound probe is placed in the vagina to see the follicles, and a thin needle attached to a suction device passes through the vaginal wall into each follicle to collect the eggs. Several eggs can usually be collected in about 20 minutes. If the ovaries cannot be reached this way, an abdominal ultrasound may be used instead.
• You can usually go home the same day, but arrange for someone to accompany you and avoid driving for 24 hours after anaesthesia.
• Mild cramping, bloating, a feeling of fullness and light spotting are common afterwards.
• Contact your clinic urgently for severe pain, heavy bleeding, fever or difficulty urinating.
More on this in our post tagged egg retrieval.
Step 5: Sperm collection and preparation
On the morning of retrieval, the male partner provides a semen sample, usually by masturbation at the clinic. Sperm can also be collected earlier and frozen. If there are no sperm in the ejaculate, a doctor can retrieve sperm directly from the testicle, and donor sperm is another option. In the lab, healthy, active sperm are separated from the rest of the semen.
Step 6: Fertilization in the laboratory
Embryologists use one of two methods to bring eggs and sperm together:
| Method | How it works | Commonly used when |
| Conventional insemination | Prepared sperm and mature eggs are placed together in an incubator and fertilization happens on its own | Sperm quality is normal |
| ICSI (intracytoplasmic sperm injection) | A single healthy sperm is injected directly into each mature egg | Low sperm count, poor movement or shape, or failed fertilization in a previous cycle |
ICSI is a powerful technique for male-factor infertility, but it is not automatically needed for everyone. If your clinic recommends ICSI for all patients, ask why, because it adds to the cost. Cleveland Clinic reports that on average about 70% of mature eggs fertilize.
Step 7: Embryo development and grading
Over the next 3 to 6 days, embryologists watch each embryo grow. By day 3 a healthy embryo typically has about 6 to 10 cells, and by day 5 or 6 the best embryos reach the blastocyst stage, a rapidly dividing ball of cells in which an inner group will become the baby and an outer group will form the placenta. Embryos are graded on cell number and speed of division, symmetry of cells, the amount of fragmentation and, for blastocysts, the quality of the inner cell mass and outer layer.

Not every embryo reaches the blastocyst stage. Cleveland Clinic gives an illustrative example of how numbers fall at each stage:
| Stage (illustrative example) | Approx. number | Note |
| Mature eggs retrieved | 10 | Immature eggs cannot be used for ICSI |
| Eggs that fertilize (about 70%) | 7 | On average |
| Embryos that reach blastocyst (about 50%) | 3 to 4 | The rest usually stop developing |
This is why a single cycle that produces many eggs does not guarantee a transferable embryo, and why the number of eggs retrieved matters more than the number of injections taken.
Step 8: Optional lab procedures
• Preimplantation genetic testing (PGT). A few cells are removed from the embryo and tested for a specific genetic disease or for the correct number of chromosomes. Mayo Clinic notes this can lower, but not remove, the chance of passing on a genetic problem, so prenatal testing may still be advised.
• Assisted hatching. A small opening is made in the embryo’s outer shell before transfer. It has been used in older patients or after failed cycles, and in frozen embryos whose shell may have hardened, although the evidence for routine use is limited (see the add-ons section below).
• Embryo freezing (cryopreservation). Spare good-quality embryos can be frozen and stored. Most survive thawing, though not all. Read Cleveland Clinic’s page on embryo cryopreservation.
Step 9: Embryo transfer
Embryo transfer is usually the simplest part of the cycle. A speculum is placed in the vagina and a thin, soft catheter carrying the embryo in a tiny drop of fluid is passed through the cervix into the uterus, often guided by ultrasound. It takes less than 10 minutes, does not usually require anaesthesia and feels similar to a Pap smear. You may be given a mild sedative if you are anxious.
• Fresh transfer. The embryo is transferred within about 3 to 7 days of egg retrieval and has not been frozen.
• Frozen embryo transfer (FET). Embryos created earlier are thawed and transferred after your uterus is prepared with hormones. Cleveland Clinic notes that FET is increasingly common, partly for logistical reasons and partly because it can be more likely to result in a live birth.
Step 10: The two-week wait and pregnancy test
After transfer you continue progesterone (and often estrogen) as prescribed. A blood test for beta-hCG, the pregnancy hormone, is done about 9 to 14 days after transfer, depending on your clinic and the day of the embryo. Testing at home too early can give a false negative or a confusing result, so wait for the clinic’s date.
The “two-week wait” is often the hardest stage emotionally. We cover what feels normal and what does not in the section on life after embryo transfer.
What if the cycle is cancelled or no embryo can be transferred?
Sometimes an IVF cycle must be stopped before egg retrieval, or no embryos are available for transfer. Common reasons include too few follicles developing, ovulation happening too early, too many follicles developing (which raises the risk of ovarian hyperstimulation syndrome), or other medical issues. If this happens, your doctor will usually adjust the medicines or protocol for the next attempt, or discuss other options such as donor eggs.
IVF timeline at a glance
| Phase | Typical time | What is happening |
| Evaluation and preparation | Several weeks to a few months | Tests for both partners, folic acid, lifestyle changes, planning |
| Cycle control (if used) | About 1 to 3 weeks | Birth control pills or estrogen to time the cycle |
| Ovarian stimulation | 8 to 14 days | Daily injections, scans and blood tests |
| Trigger and egg retrieval | 34 to 36 hours apart | Final egg maturation and egg pick-up |
| Fertilization and embryo culture | 3 to 6 days | Lab fertilization and embryo growth |
| Embryo transfer | Day 3 or day 5 to 6 | Embryo placed in the uterus (or frozen for later) |
| Two-week wait | About 9 to 14 days | Medicines continue; blood pregnancy test at the end |
Types of IVF and Related Procedures
There is no single “IVF treatment”. Your plan is built around your diagnosis, age and goals. The main variations include:
| Type | What it involves and who it may suit |
| Conventional IVF | Eggs and sperm are mixed in a dish for natural fertilization; suited to normal sperm quality |
| IVF with ICSI | One sperm is injected into each mature egg; used for male-factor infertility or previous fertilization failure |
| Frozen embryo transfer (FET) | Embryos created in an earlier cycle are thawed and transferred; useful when a fresh transfer is not advisable or when extra embryos are available |
| Donor egg IVF | Eggs from a young, healthy donor are used, often for women with very low ovarian reserve or poor egg quality; see our donor egg IVF guide |
| Donor sperm IVF | Sperm from a screened donor is used when there is no sperm or a serious genetic risk in the male partner |
| Natural-cycle or mild (mini) IVF | No or low-dose stimulation, resulting in fewer eggs; may suit selected patients, but per-cycle success can be lower |
| IVF with PGT | Embryo biopsy and genetic testing before transfer, for known genetic conditions or selected indications |
| Egg or embryo freezing | Used for fertility preservation before cancer treatment or to delay pregnancy |
| Gestational carrier (surrogacy) | Embryos are transferred to another woman who carries the pregnancy; regulated by law in India; see IVF vs surrogacy |
IVF vs IUI: What Is the Difference?
IVF and IUI are often mentioned together, but they work very differently. In IUI, a prepared sample of sperm is placed directly into the uterus around the time of ovulation, and fertilization still takes place inside the body. In IVF, fertilization happens in the laboratory. Cleveland Clinic notes that IUI is less expensive and less invasive but has a lower success rate per cycle.
| IUI | IVF | |
| Where fertilization happens | Inside the woman’s body | In the laboratory |
| Medicines | None or mild ovulation drugs | Injectable hormones for stimulation |
| Procedures | Sperm placed in the uterus with a catheter | Egg retrieval, lab fertilization, embryo transfer |
| Cost and invasiveness | Lower | Higher |
| Success per cycle | Lower | Higher |
| Often considered when | Mild male factor, unexplained infertility, cervical factors, ovulation problems | Blocked tubes, severe male factor, endometriosis, advanced age, repeated IUI failure |
To learn more about the lower-tech option, read our beginner’s guide to IUI treatment, the page on IUI treatment cost and the article on IUI pregnancy symptoms.
IVF Add-Ons: What Has Evidence and What Does Not
Many clinics offer extras on top of a standard IVF cycle, often at additional cost. These are known as add-ons, and they are one of the most important topics for patients to understand. Examples include embryo glue, time-lapse imaging, assisted hatching, endometrial scratching, endometrial receptivity testing, PGT-A (testing embryos for chromosome numbers in patients without a known genetic condition), immune treatments and sperm selection techniques.
The UK regulator, the Human Fertilisation and Embryology Authority (HFEA), publishes a colour-coded rating of add-ons based on the quality of evidence. When it updated the system in 2023, it said that for most patients the evidence that add-ons improve the chance of a baby is missing or unreliable, and that add-ons without strong evidence should be offered only in a research setting (HFEA add-on ratings). Reports on the update noted that none of the rated add-ons had received a green light for improving live birth. The European Society of Human Reproduction and Embryology (ESHRE) reached a similar conclusion in its 2023 good-practice recommendations covering 42 add-ons, concluding that only a few are recommended for specific groups and most lack good evidence for routine use (ESHRE add-on guidance).
| Questions to ask before paying for any add-on• What exactly is this expected to improve, and in which patients?• What good-quality studies show that it increases live birth rates, not just pregnancy tests or embryo grades?• Are there risks or downsides?• What is the extra cost, and would a further standard cycle give a better chance for the same money?• Is it right for my specific diagnosis? (For example, testing an embryo for a known inherited condition is a different situation from routine screening for everyone.) |
This does not mean every add-on is useless. A few have a clear role for specific patients, such as ICSI for severe male-factor infertility or PGT for a known genetic disorder. The point is to make an informed choice, not to assume that more procedures always mean better results. Ratings change as new studies appear, so check the latest guidance with your doctor.
IVF Success Rates: What Are Your Chances?
“What are my chances?” is the most important and most misunderstood question in IVF. The honest answer is that it depends mainly on the age of the woman whose eggs are used, and on how success is measured.
Live birth rate by age (per egg retrieval)
The table below shows US national data for 2019 as reported by Cleveland Clinic using CDC figures. These are live births per egg retrieval using the patient’s own eggs.
| Age group | Average live birth rate per egg retrieval |
| Under 35 | 46.7% |
| 35 to 37 | 34.2% |
| 38 to 40 | 21.6% |
| 41 to 42 | 10.6% |
| 43 and above | 3.2% |
UK figures tell the same story. HFEA data show that live births per embryo transferred in 2022 had risen to around 26% for patients aged 35 to 37 (up from 19% in 2012) and around 18% for patients aged 38 to 39 (up from 14%), while stressing that age remains one of the most important factors (HFEA preliminary trends 2022). The CDC national summary also offers an IVF Success Estimator tool that lets patients estimate their own chances.
| Understand the numbers you are shown• Per cycle started counts everyone who begins medicines, including cycles cancelled before retrieval.• Per egg retrieval counts only cycles where eggs were collected.• Per embryo transfer counts only cycles where an embryo was actually transferred, so it looks higher.• Cumulative rate adds up the chance across fresh and frozen transfers from one retrieval, or across several cycles.A clinic that quotes only the most flattering figure may not be giving you the full picture. Ask for age-wise live birth data, not just “pregnancy rate”. |
Factors that affect success
• Maternal age. The younger the woman, the higher the chance of a healthy baby using her own eggs. People aged 40 and above are often counselled about donor eggs.
• Embryo quality and stage. Transfer of more developed embryos, such as blastocysts, is linked with higher pregnancy rates, but not all embryos survive to that stage.
• Reproductive history. People who have previously given birth are more likely to succeed; the chances fall after several unsuccessful IVF attempts.
• Cause of infertility. For example, severe endometriosis lowers the chances compared with unexplained infertility, while a healthy egg supply raises them.
• Sperm quality. Poor semen quality can reduce fertilization and embryo development.
• Uterine factors. The thickness and health of the lining, fibroids, polyps and scarring all matter.
• Lifestyle. Smoking, obesity, alcohol, drugs and excess caffeine can reduce success; smokers tend to have fewer eggs retrieved and more miscarriages.
• the clinic. Laboratory quality and embryology expertise play a major role in results.
Why IVF cycles fail
IVF can fail at any step. Cleveland Clinic lists causes such as premature ovulation, no eggs developing, too many eggs developing, eggs not fertilizing, poor sperm quality, embryos that stop growing or fail to implant, and problems with egg retrieval or embryo transfer. Many failures are due to chromosomal errors in the embryo, which become more frequent with age and are not anyone’s fault. After a failed cycle, a detailed review with your doctor helps decide what to change.
Remember that success is often cumulative. Many people do not conceive in the first cycle but go on to have a baby after further attempts. Indian outcomes vary by clinic and patient profile, so ask your own clinic for its verified age-wise results.
How Much Does IVF Treatment Cost in India?
IVF costs vary by city, clinic, laboratory technology, medicines and the type of cycle. The ranges below are approximate and meant only to help with planning. Always request an itemised written estimate.
| Type of cycle | Approximate cost in India |
| Basic IVF cycle | ₹1,00,000 to ₹1,50,000 |
| IVF with ICSI | ₹1,50,000 to ₹2,00,000 |
| Frozen embryo transfer (FET) | ₹30,000 to ₹60,000 |
| Donor egg IVF | ₹2,00,000 to ₹3,00,000 |
| IVF with PGT | ₹2,50,000 to ₹3,50,000 |
Costs may vary. Contact Dr Curo for a personalized consultation and accurate pricing.
What affects the final bill?
• Medicine dose and brand, which depend on your age, weight and ovarian response.
• Whether ICSI, PGT, assisted hatching or other add-ons are used.
• Embryo freezing and annual storage fees.
• Additional cycles, since a single cycle may not be enough.
• Consultation, scan, blood test and counselling charges, which may or may not be bundled.
• Donor egg or sperm, and legal paperwork for third-party reproduction.
Ask exactly what the package includes, what is billed separately, what happens if the cycle is cancelled, and whether a refund or credit applies. WHO has pointed out that in many countries fertility treatment is mostly paid out of pocket and can cause financial hardship, so planning for more than one cycle protects you from unpleasant surprises. For lower-cost first-line treatment, see our page on IUI treatment cost.
IVF Risks, Side Effects and Safety
IVF is generally safe and has been used for more than four decades, but like all medical treatments it has risks. Knowing them helps you spot problems early. For a deeper look, read our full guide on IVF risks and complications and the ASRM patient fact sheet.
Common side effects of fertility medicines
• Bloating, mild abdominal discomfort and enlarged ovaries
• Mood swings, irritability and fatigue
• Breast tenderness and headaches
• Nausea, hot flashes and bruising at injection sites
Most settle within days after the retrieval or when the medicines stop. See our tag page on IVF side effects on mother.

Less common but important risks
| Risk | What it means | What helps |
| Ovarian hyperstimulation syndrome (OHSS) | Ovaries become swollen and painful after fertility medicines. Mild cases cause bloating, nausea and diarrhoea; rarely, severe cases cause rapid weight gain, shortness of breath and very little urine | Individualized dosing, careful monitoring, adjusting the trigger and freezing embryos to transfer later |
| Egg retrieval complications | Bleeding, infection or injury to the bowel, bladder or a blood vessel, and anaesthesia risks; all uncommon | Skilled ultrasound-guided technique and a well-equipped setting |
| Multiple pregnancy | Twins or more raise the risk of high blood pressure, diabetes, early labour and low birth weight | Transferring a single embryo whenever possible |
| Ectopic pregnancy | The embryo attaches outside the uterus, often in a tube; a small percentage of IVF pregnancies | Early ultrasound after a positive test |
| Miscarriage | Rates are similar to natural conception and rise with age: about 15% in the 20s to over 50% in the 40s | Embryo selection, treating uterine problems, age-appropriate counselling |
| Preterm birth and low birth weight | Slightly higher risk in IVF pregnancies | Single embryo transfer and good antenatal care |
| Birth defects | About 2% of all babies are born with a birth defect; some studies show a slightly higher rate after IVF, possibly related to infertility itself or parental age | Preconception health and prenatal screening |
| Cancer | Early concerns about ovarian tumours have not been supported by more recent studies; no significant increase in breast, uterine, cervical or ovarian cancer has been found | Routine screening as advised |
| Emotional stress | Anxiety and low mood are common during treatment | Counselling, support groups, open communication |
| Call your clinic urgently if you have• Severe or worsening abdominal or pelvic pain, or a swollen abdomen• Heavy vaginal bleeding• Fever above 38°C (100.5°F)• Rapid weight gain, shortness of breath or persistent vomiting• Very little urine or blood in your urineThese can be signs of infection, OHSS, ovarian torsion or other complications that need prompt treatment. |
Is an IVF pregnancy high risk? Cleveland Clinic points out that an IVF pregnancy is not automatically high risk; it becomes so if there are other factors such as advanced maternal age, twins or high blood pressure.
Life After Embryo Transfer: The Two-Week Wait
After transfer you can usually return to your normal routine. Your ovaries may still be enlarged, so vigorous exercise and intercourse may be uncomfortable; ask your clinic how long to avoid them. Strict bed rest is not required.
What is normal
• Light spotting or a small amount of clear or bloody discharge soon after transfer
• Mild cramping and bloating
• Breast tenderness from high estrogen levels
• Constipation
• Tiredness and mood swings from progesterone
Symptoms in the two-week wait do not reliably predict whether you are pregnant, since progesterone itself causes pregnancy-like symptoms. Read more in our tag collection on IVF pregnancy symptoms.
Practical tips for the wait
• Take every medicine exactly as prescribed, particularly progesterone.
• Eat balanced meals, stay hydrated and rest well; choose gentle walks over intense workouts.
• Avoid smoking, alcohol and unprescribed supplements or medicines.
• Do not test at home before the date your clinic gives you.
• Lean on your partner, a friend or a counsellor; this is a period when many people feel anxious.
If the test is positive
Your clinic will repeat the hormone test, arrange an early ultrasound to confirm that the pregnancy is in the uterus and then refer you for regular antenatal care. Progesterone is often continued into early pregnancy.
If the test is negative
A negative result is painful, even when you have been told to expect that it may take more than one attempt. You will usually stop progesterone and have your period within about a week. Cleveland Clinic notes that most centres advise waiting for at least one complete menstrual cycle, roughly 4 to 6 weeks, before starting another cycle. Use this time to review the cycle with your doctor: how many eggs were collected, how many fertilized, embryo quality, and whether any change in medicines, lab technique or testing is justified.
How to Prepare Your Body for IVF
IVF cannot be won by lifestyle alone, but healthy habits can support the process. Mayo Clinic highlights several lifestyle factors that affect IVF success, and its overview of female fertility and lifestyle is a useful companion.

• Take folic acid. Start at least three months before transfer, as advised by your doctor.
• Aim for a healthy weight. Both obesity and being significantly underweight can reduce the chance of pregnancy.
• Quit smoking, and avoid alcohol and recreational drugs. Smoking is linked to fewer eggs retrieved and more miscarriages; it also harms sperm.
• Limit caffeine.
• Eat a balanced diet rich in vegetables, fruit, whole grains, protein and healthy fats. Check for iron deficiency, which is common in Indian women, and correct it with your doctor’s advice.
• Manage chronic conditions such as thyroid disease, diabetes and high blood pressure before starting.
• Sleep well and manage stress. Stress does not cause infertility, but treatment is easier when you are rested.
• Involve the male partner. Sperm health improves with avoiding tobacco and heavy alcohol, staying active, avoiding heat exposure such as prolonged hot baths, and treating infections or varicocele when advised.
• Check all medicines and supplements with your fertility doctor, including herbal products.
IVF and Emotional Wellbeing
The emotional side of IVF is as significant as the physical side. Cleveland Clinic notes that many people struggle with anxiety and depression during treatment, and Mayo Clinic highlights that IVF can be draining for the body, mind and finances. Many couples experience:
• Anxiety and stress during the waiting periods
• Grief and disappointment if a cycle fails
• Strain in the relationship, including communication difficulties
• Isolation, social pressure and pressure from family
• Worry about money and time away from work
Ways to cope include:
• Talking openly with your partner about what each of you needs.
• Seeing a counsellor or therapist with experience in fertility issues.
• Joining a support group so you can speak to people who understand.
• Deciding in advance how many cycles you are prepared to attempt and what your next steps will be.
• Taking breaks between cycles when you need them.
You are not alone in this. If you feel persistently hopeless, cannot sleep or are unable to function, please speak to your doctor or a mental health professional.
IVF in India: The ART (Regulation) Act, 2021
For many years, Indian ART clinics worked under guidelines issued by the Indian Council of Medical Research (ICMR) in 2005, which had no force of law. That changed with the Assisted Reproductive Technology (Regulation) Act, 2021, passed in December 2021 and in force from January 2022 along with the Surrogacy (Regulation) Act. In simple terms, the law:
• Requires registration. Every ART clinic and ART bank must be registered with the National Registry, and national and state boards oversee them.
• Sets eligibility. ART services are for married couples and women within the age limits under Section 21(g): 21 to 50 years for the woman and 21 to 55 years for the man. Courts have heard several petitions on how this applies, so ask your clinic about your own situation.
• Regulates donors. Donors must meet age and screening requirements; the rules prescribe donor age bands, for example 21 to 55 years for sperm donors and 23 to 35 years for oocyte donors. Confirm the current rules with your clinic.
• Limits the number of embryos transferred to protect mothers and babies from the risks of multiple pregnancy.
• Prohibits sex selection and misuse of ART.
• Protects patients and children with requirements for consent, record-keeping, storage and penalties for violations.
Practical advice: only go to a clinic that can show you its ART registration, ask for its embryologists’ qualifications and read every consent form carefully before you sign.
How to Choose an IVF Clinic
The clinic you choose affects both your experience and your results. When shortlisting, consider:
• Registration and credentials. Is it registered under the ART Act? Are the doctors qualified in reproductive medicine and the embryologists experienced?
• Transparent results. Ask for live birth rates by age group, and the number of cycles behind the figures. Be wary of clinics quoting only “pregnancy rates” or only their best results.
• Laboratory quality. The embryology lab, incubators, culture conditions and quality control are critical.
• Personalized protocols. Your treatment should be built around your tests, not a standard package for everyone.
• Clear pricing. Itemised estimates, with what is included and excluded.
• Single embryo transfer policy and how the clinic prevents multiple pregnancy and OHSS.
• Counselling and support. Is emotional support part of the programme?
• Communication. Will you have access to your doctor, and who handles emergencies out of hours?
Questions to ask at your first consultation
• What is your success rate for patients like us, by age and diagnosis?
• What is your live birth rate per embryo transfer and per egg retrieval?
• What percentage of your births are twins or higher?
• What is the total cost, and what is not included?
• Can we freeze and store embryos, for how long and at what cost?
• Which add-ons do you recommend for us, and why?
• What happens if the cycle is cancelled, or if we need a second opinion?
Alternatives to IVF
IVF is not the only way to build a family, and it is not right for everyone. Depending on your diagnosis, your doctor may discuss:
• Ovulation induction with medicines, often combined with timed intercourse.
• IUI, a less invasive option for selected couples. See our IUI guide.
• Surgery to treat tubal disease, endometriosis, fibroids, polyps or varicocele.
• Donor eggs or donor sperm when your own gametes are unlikely to succeed. See donor egg IVF.
• Surrogacy, which in India is regulated by law. Read IVF vs surrogacy.
• Adoption, which is a rewarding path for many families.
• Living child-free, a valid choice for some after long struggles.

IVF Myths vs Facts
| Myth | Fact |
| IVF always works | No fertility treatment can guarantee a baby. Success depends on age, diagnosis, embryo quality and the clinic. |
| IVF is only for older women | IVF is advised for many younger women and men too, for blocked tubes, male factor, endometriosis and other reasons. |
| IVF babies are not normal or healthy | Most IVF babies are healthy. There is a small increase in risks such as prematurity and low birth weight, which is linked partly to multiple pregnancy and parental factors. |
| IVF causes cancer | Current evidence does not show a significant increase in breast, uterine, cervical or ovarian cancer after IVF. |
| You need complete bed rest after transfer | Bed rest is not required. Gentle routine activity is fine; avoid strenuous exercise as advised. |
| Only the woman needs to be tested | Male factor contributes to a large share of infertility, so a semen analysis is a basic part of the evaluation. |
| More add-ons mean better chances | Most add-ons lack high-quality evidence. Ask about the evidence and the cost before agreeing. |
| IVF means the baby grows in a test tube | Fertilization happens in a lab dish for a few days. The embryo is then transferred and the baby develops in the mother’s uterus. |
IVF Glossary: Terms You Will Hear
| Term | Meaning |
| AMH | Anti-Müllerian hormone; a blood test that helps estimate ovarian reserve |
| ART | Assisted reproductive technology; treatments that handle eggs, sperm or embryos |
| Blastocyst | A day 5 or 6 embryo with an inner cell mass and outer layer |
| Beta-hCG | The pregnancy hormone measured in the blood test after transfer |
| Cryopreservation | Freezing eggs, sperm or embryos for later use |
| FET | Frozen embryo transfer |
| Follicle | A fluid-filled sac in the ovary that contains an egg |
| ICSI | Intracytoplasmic sperm injection; one sperm injected into one egg |
| IUI | Intrauterine insemination; sperm placed into the uterus |
| OHSS | Ovarian hyperstimulation syndrome; an over-response to fertility medicines |
| PGT | Preimplantation genetic testing of embryos |
| Trigger shot | The injection that completes egg maturation before retrieval |
How Dr Curo Supports Your Fertility Journey
At Dr Curo, our goal is to give you accurate, transparent and patient-centred information so you can make decisions with confidence. If you are exploring treatment, you can read more on our IVF treatment and infertility treatment pages, browse all articles in Fertility & Women Health, learn about us or contact our team to book a consultation.
A thorough evaluation will help determine the best path for your unique situation, whether that is lifestyle changes, medicines, IUI, IVF or another option.
Frequently Asked Questions About IVF Treatment
Q. What is IVF treatment in simple words?
IVF is a treatment in which eggs and sperm are combined in a laboratory to form embryos. A healthy embryo is then placed in the uterus to try to achieve pregnancy. It is used when natural conception or simpler treatments have not worked or are unlikely to work.
Q. Is IVF treatment painful?
Most people find the injections mildly uncomfortable. Egg retrieval is done under sedation or anaesthesia, so you do not feel the procedure, though cramping and bloating can follow. Embryo transfer is usually painless and feels like a Pap smear.
Q. How long does one IVF cycle take?
Active treatment from the start of injections to embryo transfer takes about 2 to 3 weeks, and about 4 to 6 weeks from preparation to the pregnancy test. Frozen transfers and extra testing can add time.
Q. How many IVF cycles will I need?
There is no fixed number. Some people succeed on the first attempt; others need two or three or more, especially at older ages. Your doctor will guide you based on your results and history.
Q. Does IVF guarantee pregnancy?
No. Even in the best circumstances no treatment can guarantee a baby, but IVF offers the highest chance per cycle among assisted reproduction methods.
Q. Are IVF babies healthy and normal?
Yes, the large majority are healthy. Studies show a slightly higher risk of prematurity and low birth weight, which is linked partly to multiple pregnancy. Good antenatal care and single embryo transfer help.
Q. What is the best age for IVF?
Younger is better for egg quality. Success declines from about 35 and falls steeply after 40. If you are over 35, do not delay seeking an evaluation.
Q. What is the difference between IVF and ICSI?
IVF is the whole treatment cycle. ICSI is one way to fertilize the eggs within an IVF cycle, by injecting a single sperm into each mature egg. It is mainly used for male-factor infertility or previous fertilization failure.
Q. Is a fresh or frozen embryo transfer better?
It depends on your situation. Frozen transfers are now very common and can be more likely to lead to a live birth in some patients, while fresh transfers are suitable in others. Your doctor will advise.
Q. When can I take a pregnancy test after embryo transfer?
Your clinic will schedule a blood test, usually 9 to 14 days after transfer. Home tests taken earlier can mislead you.
Q. Can I work and do normal activities during IVF?
Most people continue working. Light daily activity is fine. Avoid strenuous exercise, smoking, alcohol and high stress, and take a day or two off for egg retrieval and rest.
Q. How much does IVF cost in India?
A basic IVF cycle typically ranges from about ₹1,00,000 to ₹1,50,000, and costs rise with ICSI, PGT, donor gametes and additional cycles. Ask for an itemised estimate from your clinic.
Q. Can I choose the baby’s sex with IVF in India?
No. Sex selection is prohibited in India, and the ART Act forbids misuse of ART. Embryo testing is allowed only for medical reasons such as serious genetic disorders.
Q. What happens to leftover embryos?
They can usually be frozen and stored for future cycles, subject to the law and your consent. Decide in advance how long you want them stored and what should happen if you do not need them.
Q. When should I stop trying IVF?
This is a personal decision. Many people set limits based on medical advice, finances and emotional wellbeing. Your doctor can review your chances honestly after each cycle and discuss alternatives such as donor gametes.
Conclusion: Is IVF Right for You?
IVF has helped millions of people become parents, but it is a demanding treatment with real limits. The best outcomes come from understanding the process, starting with a proper evaluation, choosing a transparent and registered clinic, being realistic about age-related success rates, and looking after your emotional health along the way. If you are considering IVF, bring this guide and your questions to a fertility specialist who can look at your own test results and advise a plan.
Ready to take the next step? Explore our IVF treatment in India page or contact Dr Curo to speak to our team.
| Medical disclaimerThis article is for general information and education only. It is not a substitute for personal medical advice, diagnosis or treatment. Success rates, costs and legal rules change over time, so please confirm details with your fertility specialist and a registered ART clinic. |



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